Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.

Genetics - 1 Jul 2004

Comeron Josep M

Abstract excerpt

We report the results of a comprehensive study of the influence of gene expression on synonymous codons, amino acid composition, and intron presence and size in human protein-coding genes. First, in addition to a strong effect of isochores, we have detected the influence of transcription-associated mutational biases (TAMB) on gene composition. Genes expressed in different tissues show diverse degrees of TAMB,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Conserved Sequence
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Introns

Share to Mutation

Share to Selection, Genetic

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15280243
DOI: 10.1534/genetics.104.026351
PMCID: PMC1470943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.PMID 15280243Read ↗

Determinants of substitution rates in mammalian genes: expression pattern affects selection intensity but not mutation rate.Semantic proximity Read ↗

Exonic splicing regulatory elements skew synonymous codon usage near intron-exon boundaries in mammals.Semantic proximity Read ↗

Human cellular homeostasis buffers <i>trans</i> -acting translational effects of heterologous gene expression with very different codon usage biasSemantic proximity Read ↗

Widespread positive selection in synonymous sites of mammalian genes.Semantic proximity Read ↗

Tissue-specific evolution of protein coding genes in human and mouseSemantic proximity Read ↗

Regions of extreme synonymous codon selection in mammalian genes.Semantic proximity Read ↗

Mapping the Inter- and Intra-genic Codon Usage Landscape in <i>Homo sapiens</i>Semantic proximity Read ↗

Codon usage and amino acid identity are major determinants of mRNA stability in humansSemantic proximity Read ↗

A test of translational selection at 'silent' sites in the human genome: base composition comparisons in alternatively spliced genes.Semantic proximity Read ↗

Mammalian mutation pressure, synonymous codon choice, and mRNA degradation.Semantic proximity Read ↗

Adaptation of codon and amino acid use for translational functions in highly expressed cricket genesSemantic proximity Read ↗

Roles for Synonymous Codon Usage in Protein Biogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.