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Article

Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.

Genetics - 1 Jul 2004

Comeron Josep M

Abstract excerpt

We report the results of a comprehensive study of the influence of gene expression on synonymous codons, amino acid composition, and intron presence and size in human protein-coding genes. First, in addition to a strong effect of isochores, we have detected the influence of transcription-associated mutational biases (TAMB) on gene composition. Genes expressed in different tissues show diverse degrees of TAMB,...

Topics

Amino Acids
Base Composition
Codon
Conserved Sequence
Gene Expression
Genetics, Population
Humans
Introns
Mutation
Oligonucleotide Array Sequence Analysis
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 15280243
DOI: 10.1534/genetics.104.026351
PMCID: PMC1470943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15280243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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