Article

<i>Notch3</i> is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart looping

2024-03-28

Abstract excerpt

The TGFβ secreted factor NODAL is a major left determinant required for the asymmetric morphogenesis of visceral organs, including the heart. Yet, when this signalling is absent, shape asymmetry, for example of the embryonic heart loop, is not fully abrogated, indicating that there are other factors regulating left-right patterning. Here, we used a tailored transcriptomic approach to screen for genes asymmetricall...

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Literature Corpus work: 42df0d95-9964-56e3-a255-da129efc3154
DOI: 10.1101/2024.03.25.586543

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