Article
Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow.
Science advances - 24 Jul 2026
Ochandorena-Saa Amaia, Perthame Emeline, Oulerich Zoé, Chamolly Alexander, Blisnick Thierry, Lokmer Johanna, Rouillon Cécile, Bastin Philippe, Meilhac Sigolène M
Abstract excerpt
Left-right symmetry breaking in mice is considered to occur via node leftward fluid flow. The molecular cascade within the node has been reconstructed at high resolution; however, its importance for organogenesis remains poorly understood. Here, we show in mutants for the motile cilium component CCDC40 that 70% of mice develop normal situs at birth despite abrogation of node flow. The discrete morphospace output,...
Topics
- Animals
- Mice
- Phenotype
- Body Patterning
- Wnt Proteins
- Nodal Protein
- Wnt Signaling Pathway
- Gene Expression Regulation, Developmental
- Mutation