Article
Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.
Nature - 9 May 1996
Lowe L A, Supp D M, Sampath K, Yokoyama T, Wright C V, Potter S S, Overbeek P, Kuehn M R
Abstract excerpt
Vertebrates have characteristic and conserved left-right (L-R) visceral asymmetries, for example the left-sided heart. In humans, alterations of L-R development can have serious clinical implications, including cardiac defects. Although little is known about how the embryonic L-R axis is establis...
Topics
- Animals
- Chick Embryo
- Embryo, Mammalian
- Embryo, Nonmammalian
- Female
- Gene Expression Regulation, Developmental
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Inbred BALB C
- Morphogenesis
- Mutation
- Nodal Protein
- RNA, Messenger
- Situs Inversus
- Transforming Growth Factor beta
- Xenopus