Article
Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2009
Ermakov Alexander, Stevens Jonathan L, Whitehill Elaine, Robson Joan E, Pieles Guido, Brooker Debra, Goggolidou Paraskevi, Powles-Glover Nicola, Hacker Terry, Young Stephen R, Dear Neil, Hirst Elizabeth, Tymowska-Lalanne Zuzanna, Briscoe James, Bhattacharya Shoumo, Norris Dominic P
Abstract excerpt
Vertebrate organs show consistent left-right (L-R) asymmetry in placement and patterning. To identify genes involved in this process we performed an ENU-based genetic screen. Of 135 lines analyzed 11 showed clear single gene defects affecting L-R patterning, including 3 new alleles of known L-R genes and mutants in novel L-R loci. We identified six lines (termed "gasping") that, in addition to abnormal L-R...
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