A role of the cryptic gene in the correct establishment of the left-right axis.

doi:10.1016/s0960-9822(00)80059-7

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Article

A role of the cryptic gene in the correct establishment of the left-right axis.

Current biology : CB - 18 Nov 1999

Gaio U, Schweickert A, Fischer A, Garratt A N, Müller T, Ozcelik C, Lankes W, Strehle M, Britsch S, Blum M, Birchmeier C

Abstract excerpt

During vertebrate embryogenesis, a left-right axis is established. The heart, associated vessels and inner organs adopt asymmetric spatial arrangements and morphologies. Secreted growth factors of the TGF-beta family, including nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries [1] [2] [3]. In zebrafish, nodal signalling requires the presence of one-eyed pinhead (oep), a member...

Topics

Alleles
Animals
Animals, Newborn
Dextrocardia
Embryonic and Fetal Development
Fetal Heart
Gene Expression Regulation, Developmental
Genotype
Growth Substances
Heart Defects, Congenital
Homeodomain Proteins
Intercellular Signaling Peptides and Proteins
Left-Right Determination Factors

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Mesoderm

Mice

Mice, Knockout

Morphogenesis

Nodal Protein

Source

Open in PubMed

Identifiers

PMID: 10574770
DOI: 10.1016/s0960-9822(00)80059-7

Genes

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