Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role of the cryptic gene in the correct establishment of the left-right axis.

Current biology : CB - 18 Nov 1999

Gaio U, Schweickert A, Fischer A, Garratt A N, Müller T, Ozcelik C, Lankes W, Strehle M, Britsch S, Blum M, Birchmeier C

Abstract excerpt

During vertebrate embryogenesis, a left-right axis is established. The heart, associated vessels and inner organs adopt asymmetric spatial arrangements and morphologies. Secreted growth factors of the TGF-beta family, including nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries [1] [2] [3]. In zebrafish, nodal signalling requires the presence of one-eyed pinhead (oep), a member...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic and Fetal Development
Share to Fetal Heart

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Growth Substances

Share to Homeobox Protein PITX2

Share to Mesoderm

Share to Nodal Protein

Share to Paired Box Transcription Factors

Share to Viscera

Source

Identifiers

PMID: 10574770
DOI: 10.1016/s0960-9822(00)80059-7

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role of the cryptic gene in the correct establishment of the left-right axis.PMID 10574770Read ↗

Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.Semantic proximity Read ↗

The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning.Semantic proximity Read ↗

The Axenfeld-Rieger syndrome gene <i>FOXC1</i> contributes to left-right patterningSemantic proximity Read ↗

Classification of left-right patterning defects in zebrafish, mice, and humans.Semantic proximity Read ↗

Molecular basis of left-right asymmetry.Semantic proximity Read ↗

Understanding laterality disorders and the left-right organizer: Insights from zebrafishSemantic proximity Read ↗

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.Semantic proximity Read ↗

Function of Rieger syndrome gene in left-right asymmetry and craniofacial development.Semantic proximity Read ↗

<i>Notch3</i> is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart loopingSemantic proximity Read ↗

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.Semantic proximity Read ↗

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Semantic proximity Read ↗

The genetics of left-right development and heterotaxiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.