Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

Nature communications - 1 Jan 2013

Noël Emily S, Verhoeven Manon, Lagendijk Anne Karine, Tessadori Federico, Smith Kelly, Choorapoikayil Suma, den Hertog Jeroen, Bakkers Jeroen

Abstract excerpt

Breaking left-right symmetry in bilateria is a major event during embryo development that is required for asymmetric organ position, directional organ looping and lateralized organ function in the adult. Asymmetric expression of Nodal-related genes is hypothesized to be the driving force behind regulation of organ laterality. Here we identify a Nodal-independent mechanism that drives asymmetric heart looping in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Actomyosin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Patterning

Share to Embryo, Nonmammalian

Share to Gene Expression Regulation, Developmental

Share to Nodal Protein

Share to Zebrafish

Source

Identifiers

PMID: 24212328
DOI: 10.1038/ncomms3754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.PMID 24212328Read ↗

A cellular framework for gut-looping morphogenesis in zebrafish.Semantic proximity Read ↗

Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic processSemantic proximity Read ↗

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development.Semantic proximity Read ↗

Heart and gut chiralities are controlled independently from initial heart position in the developing zebrafish.Semantic proximity Read ↗

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.Semantic proximity Read ↗

<i>Notch3</i> is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart loopingSemantic proximity Read ↗

Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetrySemantic proximity Read ↗

Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton.Semantic proximity Read ↗

The genetic landscape of cardiovascular left-right patterning defects.Semantic proximity Read ↗

The genetics of left-right development and heterotaxiaSemantic proximity Read ↗

Left–right asymmetry and congenital cardiac defects: Getting to the heart of the matter in vertebrate left–right axis determinationSemantic proximity Read ↗

Knowing left from right: the molecular basis of laterality defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.