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Article

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.

Mechanisms of development - 1 Nov 2004

Vincent Stéphane D, Norris Dominic P, Le Good J Ann, Constam Daniel B, Robertson Elizabeth J

Abstract excerpt

In all vertebrates, invariant left/right (L/R) positioning and organization of the internal viscera is controlled by a conserved pathway. Nodal, a member of the TGFbeta superfamily is a critical upstream component responsible for initiating L/R axis determination. Asymmetric Nodal expression in the node preceeds and foreshadows morphological L/R asymmetry. Here we address the mechanism of Nodal activation in the...

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Share to Body Patterning
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15454269
DOI: 10.1016/j.mod.2004.06.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.PMID 15454269Read ↗

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