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Article

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

Scientific reports - 11 Jul 2018

Dykes Iain M, Szumska Dorota, Kuncheria Linta, Puliyadi Rathi, Chen Chiann-Mun, Papanayotou Costis, Lockstone Helen, Dubourg Christèle, David Véronique, Schneider Jurgen E, Keane Thomas M, Adams David J, Brown Steve D M, Mercier Sandra, Odent Sylvie, Collignon Jérôme, Bhattacharya Shoumo

Abstract excerpt

ZIC2 mutation is known to cause holoprosencephaly (HPE). A subset of ZIC2 HPE probands harbour cardiovascular and visceral anomalies suggestive of laterality defects. 3D-imaging of novel mouse Zic2 mutants uncovers, in addition to HPE, laterality defects in lungs, heart, vasculature and viscera. A strong bias towards right isomerism indicates a failure to establish left identity in the lateral plate mesoderm...

Topics

Animals
Body Patterning
Cilia
Holoprosencephaly
Mesoderm
Mice
Morphogenesis
Mutation
Nodal Protein
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Signal Transduction

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29992973
DOI: 10.1038/s41598-018-28714-1
PMCID: PMC6041270

Genes

ZIC2
NODAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.PMID 29992973Read ↗

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