Article
Of mice and men: dissecting the genetic pathway that controls left-right asymmetry in mice and humans.
American journal of medical genetics - 1 Jan 2000
Schneider H, Brueckner M
Abstract excerpt
The increasing ability to manipulate the mouse genetically has created a model system that is both accessible and an accurate mirror of human development. A combination of analysis of existing spontaneous mouse mutations and creation of targeted mutations has identified at least z24 genes involved in the specification of mouse left-right asymmetry. These genes function in a carefully orchestrated manner first to...
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