Article

The deacetylase dependent and independent role of HDAC3 in cardiomyopathy

2022-12-24

Abstract excerpt

<h4>Background</h4> Cardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac function. HDAC3 commonly functions as co-repressor by removing acetyl moieties from histone tails. However, a deacetylase-independent role of HDAC3 has also been described. Cardiac deletion of HDAC3 causes reduced cardiac contractility accompanied by lipid accumulation. The molecular function of HDAC3 in cardi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4271a92c-a22f-51b0-9faa-6a3b4e17a32f
DOI: 10.1101/2022.12.23.521758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The deacetylase dependent and independent role of HDAC3 in cardiomyopathyDOI 10.1101/2022.12.23.521758Read

Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal MuscleSemantic proximity Read

Targeting histone deacetylase in cardiac diseasesSemantic proximity Read

Endocardial HDAC3 is required for myocardial trabeculationSemantic proximity Read

Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac HypertrophySemantic proximity Read

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model.Semantic proximity Read

Role of Histone Deacetylase and Inhibitors in Cardiovascular DiseasesSemantic proximity Read

The impact of non-cardiomyocyte <i>MYBPC3</i> expression on the development of hypertrophic cardiomyopathySemantic proximity Read

Heart-specific Rpd3 downregulation enhances cardiac function and longevity.Semantic proximity Read

Cardiac deletion of Smyd2 is dispensable for mouse heart development.Semantic proximity Read

Histone deacetylase inhibition in the treatment of heart diseaseSemantic proximity Read

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEFSemantic proximity Read

Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathySemantic proximity Read