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Article

Histone deacetylase inhibition in the treatment of heart disease

1 Jan 2008

Abstract excerpt

Recent work has demonstrated the importance of chromatin remodeling, especially histone acetylation, in the control of gene expression in the heart. Studies in preclinical models suggest that inhibition of histone deacetylase (HDAC) activity - using compounds that show promise in ongoing oncology trials - blunts pathologic growth of cardiac myocytes. Indeed, small-molecule inhibitors of HDACs are members of an...

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PMID: 18171314
DOI: 10.1517/14740338.7.1.53

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