Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model.

International journal of molecular sciences - 9 Aug 2022

Da'as Sahar Isa, Hasan Waseem, Salem Rola, Younes Nadine, Abdelrahman Doua, Mohamed Iman A, Aldaalis Arwa, Temanni Ramzi, Mathew Lisa Sara, Lorenz Stephan, Yacoub Magdi, Nomikos Michail, Nasrallah Gheyath K, Fakhro Khalid A

Abstract excerpt

Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart's contractile machinery. To investigate the c-MYBPC3 HCM-related cardiac impairment, we generated a zebrafish mypbc3-knockout model. These knockout zebrafish displayed significant morphological heart alterations related to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cardiac Myosins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic

Share to Carrier Proteins

Share to Hyperplasia

Share to Myocytes, Cardiac

Share to Transcriptome

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 36012114
DOI: 10.3390/ijms23168840
PMCID: PMC9408294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model.PMID 36012114Read ↗

Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model.Semantic proximity Read ↗

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology.Semantic proximity Read ↗

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Semantic proximity Read ↗

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.Semantic proximity Read ↗

Phenotyping cardiomyopathy in adult zebrafish.Semantic proximity Read ↗

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.Semantic proximity Read ↗

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Early Subclinical and Sex-Specific Cardiac Remodeling Precedes Heart Failure in Zebrafish with Human Actin T126I MutationSemantic proximity Read ↗

Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands.Semantic proximity Read ↗

Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic RemodelingSemantic proximity Read ↗

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathySemantic proximity Read ↗

<i>MYBPC3</i> Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.