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Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

11 Jun 2025

Abstract excerpt

-dependent histone deacetylases that regulate the key signalling pathways involved in gene transcription. 11 isoforms have been identified. Recent in vitro and in vivo studies have shown that HDACs are involved in the pathophysiology of cardiovascular diseases (CVDs) and play important roles in cell proliferation, differentiation and mitochondrial metabolism. In terms of physiological mechanisms, HDAC1-6 may play...

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PMID: 40497340
DOI: 10.1111/cpr.70077

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