Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF

Abstract excerpt

<h4>ABSTRACT</h4> Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent cardiometabolic syndrome with yet no effective therapies. Here, we report that selectively class IIa histone deacetylases (HDACs) but no other classes of HDACs are enzymatically activated in hearts from HFpEF patients and cardiometabolic HFpEF animal models. Cell type-specific and enzymatic activity-specific genetic los...

Topics

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• Histone Deacetylase Inhibitors
• Histone Deacetylase Inhibitors Research
• Histone Deacetylases
• Ligands
• Peptidase Inhibition and Analysis
• Phenotype
• Signaling Pathways in Disease
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

07920675-2f52-5687-9d96-fa20b5033ddc

DOI

10.64898/2026.01.14.699428