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Article

Heart-specific Rpd3 downregulation enhances cardiac function and longevity.

Aging - 1 Sept 2015

Kopp Zachary A, Hsieh Jo-Lin, Li Andrew, Wang William, Bhatt Dhelni T, Lee Angela, Kim Sae Yeon, Fan David, Shah Veevek, Siddiqui Emaad, Ragam Radhika, Park Kristen, Ardeshna Dev, Park Kunwoo, Wu Rachel, Parikh Hardik, Parikh Ayush, Lin Yuh-Ru, Park Yongkyu

Abstract excerpt

Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when targeted in the heart. Contested against three different stressors (oxidation, starvation and heat), heart-specific...

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Identifiers

PMID: 26399365
DOI: 10.18632/aging.100806
PMCID: PMC4600623

Genes

HDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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