Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy

Abstract excerpt

Cardiac hypertrophy occurs in association with heart diseases and ultimately results in cardiac dysfunction and heart failure. Histone deacetylases (HDACs) are post-translational modifying enzymes that can deacetylate histones and non-histone proteins. Research with HDAC inhibitors has provided evidence that the class I HDACs are pro-hypertrophic. Among the class I HDACs, HDAC2 is activated by hypertrophic...

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• Histone Deacetylase Inhibitors Research
• Peptidase Inhibition and Analysis
• Signaling Pathways in Disease