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Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle

2 Aug 2011

Abstract excerpt

Many human diseases result from the influence of the nutritional environment on gene expression. The environment interacts with the genome by altering the epigenome, including covalent modification of nucleosomal histones. Here, we report a novel and dramatic influence of diet on the phenotype and survival of mice in which histone deacetylase 3 (Hdac3) is deleted postnatally in heart and skeletal muscle. Although...

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PMID: 21808063
DOI: 10.1074/jbc.m111.277707

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