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Targeting histone deacetylase in cardiac diseases

24 Jun 2024

Abstract excerpt

Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potential new therapy for heart diseases. Cardioprotective effects of HDACi are observed in many preclinical animal models of heart diseases. Genetic mouse models have been...

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PMID: 38983721
DOI: 10.3389/fphys.2024.1405569

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