Endocardial HDAC3 is required for myocardial trabeculation

Abstract excerpt

Failure of proper ventricular trabeculation is often associated with congenital heart disease (CHD). Support from endocardial cells, including the secretion of extracellular matrix (ECM) and growth factors is critical for trabeculation. However, it is poorly understood how the secretion of ECM and growth factors is initiated and regulated by endocardial cells. We found that genetic knockout (KO) of histone deacety...

Topics

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• Cancer-related gene regulation
• Cardiac Structural Anomalies and Repair
• Cardiomyopathy and Myosin Studies
• Congenital heart defects research
• Congenital Heart Disease Studies
• Histone Deacetylase Inhibitors Research
• Peptidase Inhibition and Analysis
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

5a874e6f-39b6-55a8-b787-d030060ce448

DOI

10.1101/2023.04.12.536668