Article

Staging Alzheimer’s disease in the brain and retina of <i>B6.APP/PS1</i> mice by transcriptional profiling

2019-08-21

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a common form of dementia characterized by amyloid plaque deposition, TAU pathology, neuroinflammation and neurodegeneration. Mouse models recapitulate some key features of AD. For instance, the B6. APP/PS1 model (carrying human transgenes for mutant forms of APP and PSEN1 ) shows plaque deposition and associated neuroinflammatory responses involving both astrocyte...

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Literature Corpus work: 418395c2-8807-5c76-b0c0-10ae56844e68
DOI: 10.1101/741421

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