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Identifying Blood Transcriptome Biomarkers of Alzheimer’s Disease Using Transgenic Mice

20 Aug 2020

Abstract excerpt

The testing of pathological biomarkers of Alzheimer's disease (AD), such as amyloid beta and tau, is time-consuming, expensive, and invasive. Here, we used 3xTg-AD mice to identify and validate putative novel blood transcriptome biomarkers of AD that can potentially be identified in the blood of patients. mRNA was extracted from the blood and hippocampus of 3xTg-AD and control mice at different ages and used for...

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PMID: 32816243
DOI: 10.1007/s12035-020-02058-2

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