Article

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

2018-12-11

Abstract excerpt

<h4>Background</h4> Thousands of SNPs associated with risk of Alzheimer’s disease (AD) in genome-wide association studies (GWAS) do not reach genome-wide significance. When combined, they contribute however to a highly predictive polygenic risk score. The relevance of these subthreshold risk genes to disease, and how their combined predictive power translates into functionally relevant disease pathways, is unknow...

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Literature Corpus work: cfef6570-864b-5e35-bb24-4167bd3b76db
DOI: 10.1101/491902

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