Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s Disease

22 Jan 2016

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by early intraneuronal amyloid-β (Aβ) accumulation, extracellular deposition of Aβ peptides, and intracellular hyperphosphorylated tau aggregates. These lesions cause dendritic and synaptic alterations and induce an inflammatory response in the diseased brain. Although the neuropathological characteristics of AD have been known for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26639971
DOI: 10.3233/jad-150745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s DiseasePMID 26639971Read ↗

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammationSemantic proximity Read ↗

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.Semantic proximity Read ↗

A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s DiseaseSemantic proximity Read ↗

Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genesSemantic proximity Read ↗

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau PathologySemantic proximity Read ↗

Identifying Blood Transcriptome Biomarkers of Alzheimer’s Disease Using Transgenic MiceSemantic proximity Read ↗

Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s DiseaseSemantic proximity Read ↗

Whole transcriptome RNA-Seq reveals drivers of pathological dysfunction in a transgenic model of Alzheimer’s diseaseSemantic proximity Read ↗

Cross-species comparative hippocampal transcriptomics in Alzheimer’s diseaseSemantic proximity Read ↗

Transcriptomics in Alzheimer’s Disease: Aspects and ChallengesSemantic proximity Read ↗

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease <i> App <sup>NL-G-F</sup> </i> Knock in Mouse ModelSemantic proximity Read ↗

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.