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Article

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

17 Jan 2020

Abstract excerpt

Abstract Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involvement of AD risk variants in the transcriptional responses of two mouse models: APPswe/PS1 L166P and Thy‐TAU22. A unique...

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PMID: 31951107
DOI: 10.15252/emmm.201910606

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