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Article

Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Chintapaludi Sumana R, Uyar Asli, Jackson Harriet M, Acklin Casey J, Wang Xulong, Sasner Michael, Carter Gregory W, Howell Gareth R

Abstract excerpt

Alzheimer's disease (AD) is a common form of dementia characterized by amyloid plaque deposition, tau pathology, neuroinflammation, and neurodegeneration. Mouse models recapitulate some key features of AD. For instance, the B6.APP/PS1 model (carrying human transgenes for mutant forms of APP and PSEN1) shows plaque deposition and neuroinflammation involving both astrocytes and microglia beginning around 4-6 months...

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Identifiers

PMID: 31929156
DOI: 10.3233/JAD-190793
PMCID: PMC9066610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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