Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia

Abstract excerpt

Clonal memory, a cellular property inherited across at least two divisions, is a key driver of cell heterogeneity. To uncover its roles in human haematopoiesis, we develop high-resolution ex vivo tools that track both division and fate commitment of individual primary human haematopoietic stem and progenitor cells (HSPCs). We show that human HSPCs display a clonal memory of division, as cells descending from the s...

Topics

Open a Topic to create a Post that cites this publication.

• Computational Drug Discovery Methods
• Cytokine Signaling Pathways and Interactions

Identifiers and source

Literature Corpus work

417f8508-2154-5e41-a9c4-382165a83b42

DOI

10.1038/s41467-026-75250-y