Article

The hidden predictors of human haematopoietic clonal fate

2025-08-01

Abstract excerpt

Human haematopoietic stem and progenitor cells (HSPCs) exhibit heterogeneous lineage output, but the molecular programs underlying clonal fate remain poorly defined. To address this, we developed a human haematopoietic organoid supporting differentiation into 15 lineages and used it to track barcoded HSPC clones over time. By integrating single-cell transcriptomes, surface phenotypes, and clonal fate, we applied m...

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Literature Corpus work: ee417133-e3b2-5f3d-97af-5f02ff9e1b41
DOI: 10.1101/2025.07.28.667115

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