Back to search

Article

Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia

2025-06-24

Abstract excerpt

<h4>Summary</h4> Clonal memory, a cellular property inherited across at least two divisions, has emerged as a key driver of cell heterogeneity. To uncover its roles in human haematopoiesis, we developed high-resolution ex vivo tools that track both division and fate commitment of individual primary human haematopoietic stem and progenitor cells (HSPCs). We show that human HSPCs display a clonal memory of divisio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
364270e6-a10a-5e9f-b1bc-2b654240263f
DOI
10.1101/2025.06.24.660535
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemiaDOI 10.1101/2025.06.24.660535
Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemiaSemantic proximity
The longitudinal dynamics and natural history of clonal haematopoiesisSemantic proximity
The longitudinal dynamics and natural history of clonal haematopoiesis.Semantic proximity
The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia.Semantic proximity
Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity
Transcriptional heterogeneity predicts and enables clonal selection in ageing haematopoiesisSemantic proximity
Deciphering cell states and genealogies of human haematopoiesis.Semantic proximity
Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity
Preleukemic and leukemic evolution at the stem cell levelSemantic proximity
Clonal tracing with somatic epimutations reveals dynamics of blood ageing.Semantic proximity
The hidden predictors of human haematopoietic clonal fateSemantic proximity
Updates on Old and Weary HaematopoiesisSemantic proximity
Select a neighboring publication to make it the new centre.