Article
Clonal analysis of stem cells in differentiation and disease.
Current opinion in cell biology - 1 Dec 2016
Colom Bartomeu, Jones Philip H
Abstract excerpt
Tracking the fate of individual cells and their progeny by clonal analysis has redefined the concept of stem cells and their role in health and disease. The maintenance of cell turnover in adult tissues is achieved by the collective action of populations of stem cells with an equal likelihood of self-renewal or differentiation. Following injury stem cells exhibit striking plasticity, switching from homeostatic...
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