Article

GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis

2023-06-23

Abstract excerpt

<h4>Summary</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disorder with limited therapeutic options. Insufficient understanding of driver mutations and poor fidelity of currently available animal models has limited the development of effective therapies. Since GATA1 deficient megakaryocytes sustain myelofibrosis, we hypothesized that they may also induce fibrosis in lungs. We discovered...

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Literature Corpus work: 41411c07-83d7-515c-8cb8-18619bc8348e
DOI: 10.1101/2023.06.20.542249

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