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Article

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Molecular cell - 7 May 2020

Psaila Bethan, Wang Guanlin, Rodriguez-Meira Alba, Li Rong, Heuston Elisabeth F, Murphy Lauren, Yee Daniel, Hitchcock Ian S, Sousos Nikolaos, O'Sullivan Jennifer, Anderson Stacie, Senis Yotis A, Weinberg Olga K, Calicchio Monica L, Iskander Deena, Royston Daniel, Milojkovic Dragana, Roberts Irene, Bodine David M, Thongjuea Supat, Mead Adam J

Abstract excerpt

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine the cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we performed single-cell transcriptome profiling of 135,929 CD34+ lineage- hematopoietic stem and progenitor cells (HSPCs),...

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Source

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Identifiers

PMID: 32386542
DOI: 10.1016/j.molcel.2020.04.008
PMCID: PMC7217381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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