Article

Clonal Hematopoiesis Instructs Maladaptive Tissue Repair to Promote Fibrosis

2026-03-26

Abstract excerpt

Tissue repair is increasingly recognized as a systemic process influenced by age-associated changes beyond the injured organ itself. Clonal hematopoiesis of indeterminate potential (CHIP), a common consequence of somatic evolution in hematopoietic stem cells, has been linked to inflammatory disorders, yet whether it directly regulates tissue remodeling remains unclear. Here, we integrate population genomics, precl...

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Literature Corpus work: 2fc03fbf-f447-5c12-9756-4adfa5750687
DOI: 10.64898/2026.03.24.710438

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