Article
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Blood - 29 Oct 2020
Gleitz Hélène F E, Dugourd Aurélien J F, Leimkühler Nils B, Snoeren Inge A M, Fuchs Stijn N R, Menzel Sylvia, Ziegler Susanne, Kröger Nicolaus, Triviai Ioanna, Büsche Guntram, Kreipe Hans, Banjanin Bella, Pritchard Jessica E, Hoogenboezem Remco, Bindels Eric M, Schumacher Neele, Rose-John Stefan, Elf Shannon, Saez-Rodriguez Julio, Kramann Rafael, Schneider Rebekka K
Abstract excerpt
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to progressive bone marrow (BM) fibrosis. Although the cellular mutations involved in the pathogenesis of PMF have been extensively investigated, the sequential events that drive stromal activation and fibrosis by hematopoietic-stromal cross-talk remain elusive. Using an unbiased approach and validation in patients with MPN, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.