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Article

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

26 Feb 2017

Abstract excerpt

Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34+ cells, splenomegaly, and a propensity to evolve to acute myeloid leukemia. Moreover, the spleen and BM of patients harbor atypical, clustered megakaryocytes, which contribute to the disease by secreting profibrotic cytokines. Here, we have revealed that megakaryocytes in PMF...

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PMID: 28240607
DOI: 10.1172/jci82905

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