Back to search

Article

Integrated EVLP and single-cell profiling uncovers aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8 T cells in IPF

2025-09-08

Abstract excerpt

<title>Abstract</title> <p> Tissue-resident immune cells are crucial in chronic lung diseases, yet a comprehensive profile in human lungs is lacking. Here, we defined alterations of resident immune cells in idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease characterized by tissue inflammation and progressive scarring. Utilizing ex-vivo human lung perfusion coupled with single-cell RNA-sequen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0534f570-a7b5-5867-9274-2ecf6f1a2ab5
DOI
10.21203/rs.3.rs-7500111/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrated EVLP and single-cell profiling uncovers aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8 T cells in IPFDOI 10.21203/rs.3.rs-7500111/v1
T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary FibrosisSemantic proximity
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity
Single Cell RNA ‐Seq Identifies Cell Subpopulations Contributing to Idiopathic Pulmonary Fibrosis in HumansSemantic proximity
Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysisSemantic proximity
Spatial Transcriptomic Characterization of Novel Pathologic Niches in IPFSemantic proximity
Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary FibrosisSemantic proximity
Spatial transcriptomic characterization of pathologic niches in IPFSemantic proximity
Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung DiseasesSemantic proximity
Single-cell transcriptomics reveals CD8+ T cell structure and developmental trajectories in idiopathic pulmonary fibrosisSemantic proximity
Machine Learning and Single-Cell Analysis Identify Molecular Features of IPF-Associated Fibroblast Subtypes and Their Implications on IPF PrognosisSemantic proximity
From COVID to fibrosis: lessons from single-cell analyses of the human lungSemantic proximity
A Comprehensive Study on Molecular Characteristics and Clinical Prognosis of Immune- Related Genes in Idiopathic Pulmonary FibrosisSemantic proximity
Select a neighboring publication to make it the new centre.