Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1 low Model of Myelofibrosis.

Stem cells (Dayton, Ohio) - 1 Jan 2016

Spangrude Gerald J, Lewandowski Daniel, Martelli Fabrizio, Marra Manuela, Zingariello Maria, Sancillo Laura, Rana Rosa Alba, Migliaccio Anna Rita

Abstract excerpt

Splenomegaly is a major manifestation of primary myelofibrosis (PMF) contributing to clinical symptoms and hematologic abnormalities. The spleen from PMF patients contains increased numbers of hematopoietic stem cells (HSC) and megakaryocytes (MK). These MK express high levels of P-selectin (P-sel) that, by triggering neutrophil emperipolesis, may cause TGF-β release and disease progression. This hypothesis was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to GATA1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Megakaryocytes

Share to Neutrophils

Share to P-Selectin

Share to Primary Myelofibrosis

Share to Spleen

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 26439305
DOI: 10.1002/stem.2229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1 low Model of Myelofibrosis.PMID 26439305Read ↗

GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosisSemantic proximity Read ↗

Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.Semantic proximity Read ↗

Inflammation fuels bone marrow exhaustion caused by Samd9l mutation.Semantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPNSemantic proximity Read ↗

A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis.Semantic proximity Read ↗

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosisSemantic proximity Read ↗

STAT1 promotes megakaryopoiesis downstream of GATA-1 in miceSemantic proximity Read ↗

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactionsSemantic proximity Read ↗

TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.Semantic proximity Read ↗

Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.