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Article

A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis.

Blood - 1 May 2005

Vannucchi Alessandro M, Bianchi Lucia, Paoletti Francesco, Pancrazzi Alessandro, Torre Eugenio, Nishikawa Mitsuo, Zingariello Maria, Di Baldassarre Angela, Rana Rosa Alba, Lorenzini Rodolfo, Alfani Elena, Migliaccio Giovanni, Migliaccio Anna Rita

Abstract excerpt

Idiopathic myelofibrosis (IM) is a disease characterized by marrow fibrosis, abnormal stem/progenitor cell trafficking, and extramedullary hematopoiesis frequently associated with alterations in megakaryocytes (Mks). Mice harboring genetic alterations in either the extrinsic (ectopic thrombopoietin expression, TPO(high) mice) or intrinsic (hypomorphic GATA-1 mutation, GATA-1(low) mice) control of Mk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15665119
DOI: 10.1182/blood-2004-04-1320

Genes

TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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