Article

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

2024-10-30

Abstract excerpt

Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here, we demonstrate that cells entering quiescence select plasma membrane-resident AA transporters for endocytosis and lysosomal degradation, to match AA uptake with reduced translation. We identify the α-arrestin...

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Literature Corpus work: 410a901e-a7a3-5643-b304-61c9d6dfc632
DOI: 10.1101/2024.10.29.620655

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