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Article

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress.

Nature cell biology - 1 May 2026

Douglas Todd, Nie Pengju, Zhang Jiasheng, Abdallah Kyrillos S, Wu Zhiping, McReynolds Meghan, Iwai Kazuhiro, Peng Junmin, Gilbert Wendy V, Young Lawrence H, Crews Craig M

Abstract excerpt

The ribosome has emerged as a signalling hub that can sense metabolic perturbations and coordinate responses that either restore homeostasis or initiate cell death. The range of insults that signal via the ribosome and the mechanisms governing such cell fate decisions remain uncharacterized. Here we identify the atypical E3 ligase HOIL-1 as an unexpected node in the ribosome signalling network that resolves...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42062483
DOI: 10.1038/s41556-026-01936-6
PMCID: PMC13179138

Genes

ATF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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