Article

GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes

2023-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Growth-arrest specific 6 (GAS6) is a secreted protein that acts as a ligand for TAM receptors (TYRO3, AXL and MERTK). In humans, GAS6 circulating levels and genetic variations in GAS6 are associated with hyperglycemia and increased risk of type 2 diabetes. However, the mechanisms by which GAS6 influences glucose metabolism are not understood. Here, we show that Gas6 deficiency in mice increase...

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Literature Corpus work: 411f7e21-715c-54e6-a5fb-63ebbaf9c604
DOI: 10.1101/2023.10.19.563096

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