Article

SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

2019-02-21

Abstract excerpt

Resistance to endocrine therapies remains a major challenge for the successful management of patients with estrogen receptor-positive (ER+) breast cancers. Central to the development of resistance is the adaptive reprogramming of cellular metabolism in response to treatment. Solute carriers (SLCs) play a key role in metabolic reprogramming by transporting sugars, amino acids, and other nutrients and regulating the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 437ef95f-9e95-52e7-90c7-239f7a19ff91
DOI: 10.1101/555342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)DOI 10.1101/555342Read

Membrane transporters in cell physiology, cancer metabolism and drug responseSemantic proximity Read

The Influence of the Amino Acid Transporter LAT1 on Patient Prognosis and the Relationships between Tumor Immunometabolic and Proliferative Features Depend on Menopausal Status in Breast CancerSemantic proximity Read

Association of tamoxifen resistance and lipid reprogramming in breast cancerSemantic proximity Read

The amino acid transporter SLC7A11 expression in breast cancerSemantic proximity Read

Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transitionSemantic proximity Read

TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake.Semantic proximity Read

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescenceSemantic proximity Read

Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistanceSemantic proximity Read

Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic VulnerabilitiesSemantic proximity Read

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancerSemantic proximity Read

Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell FateSemantic proximity Read

Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancerSemantic proximity Read