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Article

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer.

International journal of molecular sciences - 22 Dec 2020

Cormerais Yann, Vučetić Milica, Parks Scott K, Pouyssegur Jacques

Abstract excerpt

The mechanistic target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. Dysregulation in the mTORC1 network underlies a wide array of pathological states, including metabolic diseases, neurological disorders, and cancer. Tumor cells are characterized by uncontrolled growth and proliferation...

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Identifiers

PMID: 33375025
DOI: 10.3390/ijms22010023
PMCID: PMC7792758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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