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Article

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Molecular cell - 6 Jul 2017

Gu Yuchao, Albuquerque Claudio P, Braas Daniel, Zhang Wei, Villa Genaro R, Bi Junfeng, Ikegami Shiro, Masui Kenta, Gini Beatrice, Yang Huijun, Gahman Timothy C, Shiau Andrew K, Cloughesy Timothy F, Christofk Heather R, Zhou Huilin, Guan Kun-Liang, Mischel Paul S

Abstract excerpt

Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter xCT. mTORC2 phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity. Genetic...

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Identifiers

PMID: 28648777
DOI: 10.1016/j.molcel.2017.05.030
PMCID: PMC5521991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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