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Article

Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter.

Scientific reports - 14 Nov 2019

Barthelemy Céline, André Bruno

Abstract excerpt

The human L-type amino acid transporter 1 (LAT1), also known as SLC7A5, catalyzes the transport of large neutral amino acids across the plasma membrane. As the main transporter of several essential amino acids, notably leucine, LAT1 plays an important role in mTORC1 activation. Furthermore, it is overexpressed in various types of cancer cells, where it contributes importantly to sustained growth. Despite the...

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PMID: 31728037
DOI: 10.1038/s41598-019-53065-w
PMCID: PMC6856120

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