Article

Characterization of the mIF4G domains in the RNA surveillance protein Upf2

2022-12-13

Abstract excerpt

Thirty percent of all mutations causing human diseases generate mRNAs with premature termination codons (PTCs). Recognition and degradation of these PTC-containing mRNAs is carried out by the mechanism known as nonsense-mediated mRNA decay (NMD). Upf2 is a scaffold protein known to be a central component of the NMD surveillance pathway. It harbors three middle domain of eukaryotic initiation factor 4G (mIF4G) doma...

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Literature Corpus work: 40ec54a6-673a-5794-af63-8cf2261901be
DOI: 10.1101/2022.12.12.519865

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