Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

23 Nov 2013

Abstract excerpt

Nonsense-mediated decay (NMD) is a eukaryotic quality control pathway, involving conserved proteins UPF1, UPF2 and UPF3b, which detects and degrades mRNAs with premature stop codons. Human UPF2 comprises three tandem MIF4G domains and a C-terminal UPF1 binding region. MIF4G-3 binds UPF3b, but the specific functions of MIF4G-1 and MIF4G-2 are unknown. Crystal structures show that both MIF4G-1 and MIF4G-2 contain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Endoplasmic Reticulum Stress and Disease
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24271394
DOI: 10.1093/nar/gkt1197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2PMID 24271394Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.Semantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2Semantic proximity Read ↗

Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3BSemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.Semantic proximity Read ↗

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Semantic proximity Read ↗

Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicaseSemantic proximity Read ↗

SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decaySemantic proximity Read ↗

In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.