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Article

UPF1-From mRNA Degradation to Human Disorders.

Cells - 27 Jan 2023

Staszewski Jacek, Lazarewicz Natalia, Konczak Julia, Migdal Iwona, Maciaszczyk-Dziubinska Ewa

Abstract excerpt

Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. It is well known as one of the key elements involved in mRNA decay pathways and participates in transcript and protein quality control in several different aspects. Firstly, UPF1 specifically degrades premature termination codon (PTC)-containing products in a...

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Identifiers

PMID: 36766761
DOI: 10.3390/cells12030419
PMCID: PMC9914065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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