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Article

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.

Nucleic acids research - 1 Aug 2014

Nicholson Pamela, Josi Christoph, Kurosawa Hitomi, Yamashita Akio, Mühlemann Oliver

Abstract excerpt

Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA decay (NMD). NMD substrates can be degraded by different routes that all require phosphorylated UPF1 (P-UPF1) as a starting point. The endonuclease SMG6, which cleaves mRNA near the PTC, is one of the three known NMD factors thought to be recruited to nonsense mRNAs via an interaction with...

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Source

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Identifiers

PMID: 25053839
DOI: 10.1093/nar/gku645
PMCID: PMC4132754

Genes

SMG6
UPF1
SMG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.PMID 25053839Read ↗

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