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Article

A highly conserved region essential for NMD in the Upf2 N-terminal domain.

Journal of molecular biology - 11 Nov 2014

Fourati Zaineb, Roy Bijoyita, Millan Claudia, Coureux Pierre-Damien, Kervestin Stéphanie, van Tilbeurgh Herman, He Feng, Usón Isabel, Jacobson Allan, Graille Marc

Abstract excerpt

Upf1, Upf2, and Upf3 are the principal regulators of nonsense-mediated mRNA decay (NMD), a cytoplasmic surveillance pathway that accelerates the degradation of mRNAs undergoing premature translation termination. These three proteins interact with each other, the ribosome, the translation termination machinery, and multiple mRNA decay factors, but the precise mechanism allowing the selective detection and...

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PMID: 25277656
DOI: 10.1016/j.jmb.2014.09.015
PMCID: PMC4871600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A highly conserved region essential for NMD in the Upf2 N-terminal domain.PMID 25277656Read ↗

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Semantic proximity Read ↗

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Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2Semantic proximity Read ↗

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Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.Semantic proximity Read ↗

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UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

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